The role of master regulators in gene regulatory networks

  • Enrique Hernández Lemus Computational Genomics Department, National Institute of Genomic Medicine, México City, México
  • K. Baca López Computational Genomics Department, National Institute of Genomic Medicine, México City, México
  • R. Lemus Computational Genomics Department, National Institute of Genomic Medicine, México City, México
  • R. García Herrera Computational Genomics Department, National Institute of Genomic Medicine, México City, México
Keywords: Gene regulatory networks

Abstract

Gene regulatory networks present a wide variety of dynamical responses to intrinsic and extrinsic perturbations. Arguably, one of the most important of such coordinated responses is the one of amplification cascades, in which activation of a few key-responsive transcription factors (termed master regulators, MRs) lead to a large series of transcriptional activation events. This is so since master regulators are transcription factors controlling the expression of other transcription factor molecules and so on. MRs hold a central position related to transcriptional dynamics and control of gene regulatory networks and are often involved in complex feedback and feedforward loops inducing non-trivial dynamics. Recent studies have pointed out to the myocyte enhancing factor 2C (MEF2C, also known as MADS box transcription enhancer factor 2, polypeptide C) as being one of such master regulators involved in the pathogenesis of primary breast cancer. In this work, we perform an integrative genomic analysis of the transcriptional regulation activity of MEF2C and its target genes to evaluate to what extent are these molecules inducing collective responses leading to gene expression deregulation and carcinogenesis. We also analyzed a number of induced dynamic responses, in particular those associated with transcriptional bursts, and nonlinear cascading to evaluate the influence they may have in malignant phenotypes and cancer.

Received: 20 Novembre 2014,  Accepted: 24 June 2015; Edited by: C. A. Condat, G. J. Sibona; DOI: http://dx.doi.org/10.4279/PIP.070011

Cite as: E Hernández-Lemus, K Baca-López, R Lemus, R García-Herrera, Papers in Physics 7, 070011 (2015)

This paper, by E Hernández-Lemus, K Baca-López, R Lemus, R García-Herrera, is licensed under the Creative Commons Attribution License 3.0.

 

Traditional Review
Published
2015-07-14
How to Cite
Hernández Lemus, E., Baca López, K., Lemus, R., & García Herrera, R. (2015). The role of master regulators in gene regulatory networks. Papers in Physics, 7, 070011. https://doi.org/10.4279/pip.070011
Section
Articles
Received 2014-11-20
Accepted 2015-06-24
Published 2015-07-14